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Ampicillin (Omnipen, Polycillin, Principen)

Dose: 1-2grams IV every 4-6 hours.

Administration: This antibiotic is good against both gram positive and gram-negative organisms but can be deactivated by beta-lactamase. This Antibiotic has a very short half-life once mixed. The Vial mate allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready for use. 

Storage: Room temperature.

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Ampicillin-sulbactam (Unasyn)

Dose: 1.5-3gm IV every six to eight hours. 

Administration: This medication has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. The Vial mate or Add-Ease System allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Azithromycin (Zithromax)

Dose: 500mg IV once per day, diluted in 250ml of Normal Saline. 

Administration: With a medium-short half-life when mixed, the options for this drug include the Vial Mate/Add-Ease system, administered via gravity.

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Aztreonam (Azactam)

Dose: 1-2gm IV three times per day. 

Administration:  This medication has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. The Vial mate or Add-Ease System allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Benzathine Penicillin (Bicillin LA)

Dose: 1.2 to 2.4 million units 

Administration: Intramuscularly 2-3 times per week.  Comes in pre-filled syringes with needles.

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Cefotaxime (Claforan)

Dose: 1-3 grams IV every 8 hours.  Diluted in 50-100ml of Normal Saline but typically is put in 20ml Syringes because it can be given IV push over 5-10 minutes. 

Administration: May be administered via Gravity Bag, Infusion Pump or IV Push.

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Ceftraroline Fosamil (Teflaro)

Dose: 600mg IV once to twice per day 

Administration:  This Antibiotic has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. The Vial mate or Add-Ease System allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Ceftriaxone (Rocephin)

Dose: 1-2 grams IV once per day, diluted in 50-100ml of Normal Saline.  Once per day dosing is common but other schedules are used (twice per day, twice per day four days per week, etc.)

Methods of administration: Includes pumps and gravity bags. IV push is sometimes used but not recommended.  

Storage: 14 Days refrigerated 45 Days frozen.

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Ciprofloxacin (Cipro)

Dose:  400mg IV twice per day.  Typically comes in pre-mix bags of 200ml. 

Administration: Gravity drip.

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Clindamycin (Cleocin)

Dose:  400mg IV twice per day.  Typically comes in pre-mix bags of 200ml. 

Administration: Gravity drip.

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Doxycycline (Vibramycin, Doxychel)

Dose: 100-400mg IV once per day, diluted in 100-400ml of Normal Saline. 

Administration: Methods of administration include pumps and gravity bags, although with a 1-4-hour infusion time the elastomeric are a better choice since there is no need to be tethered to an IV pole.

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Ertapenem (Invanz)

Dose: 1gm IV once per day. 

Administration: This medication has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. This allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Imipenem-cistlastin (Primaxin)

Dose: 500mg to 1gm IV every 12 to 8 hours 

Administration: This medication has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. This allows the Vial of medication to be connected to the bag of diluent. Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Levofloxacin (Levaquin)

Class of Antibiotic > fluoroquinolone – inhibits protein synthesis by interfering with topoisomerase. 

Dose: 500mg IV once per day, typically comes in pre-mix bags of 100ml. 

Administration: Gravity Drip

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Merropenem (Merrem)

Dose: 1gm IV every 12 to 8 hours 

Administration: This Antibiotic has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. The Vial mate or Add-Ease System allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Metronidazole (Flagyl)

Dose: 500mg IV up to three times per day.

Administration: This comes as a pre-mixed bag, given via gravity drip.

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Moxifloxacin (Avelox)

Dose: 400mg IV once per day. 

Administration: Premixed IV bags for gravity drip

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Rifampin (Rifadin)

Dose: 300mg IV twice per day or 600mg IV once per day in 500ml Normal Saline. 

Administration: This medication has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. The Vial mate or Add-Ease System allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Tigecycline (Tygacil)

Dose: 50mg IV twice per day after a 100mg loading dose.

Administration: This medication has a very short half-life once mixed, so we attach the vial of medication via a Vial mate or Add-Ease device. The Vial mate or Add-Ease System allows the Vial of medication to be connected to the bag of diluent.  Once activated the contents of the vial is reconstituted and the bag is ready to be infused via gravity drip.

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Vancomycin (Vancocin)

Dose: variable – dependent on patient weight, kidney function, etc.  Typically given one to two times per day, diluted in 250-500ml of Normal Saline depending on dose.  Weekly labs draw for kidney function and peak and trough levels of the antibiotic are necessary.

Administration: Infusion pumps or Gravity bags.

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